The structure of active serpin 1K from Manduca sexta
نویسندگان
چکیده
منابع مشابه
Primary structure of a member of the serpin superfamily of proteinase inhibitors from an insect, Manduca sexta.
A cDNA clone isolated from a fat body cDNA library from an insect, Manduca sexta, has been sequenced and shown to code for a member of the serpin family of proteinase inhibitors. The cDNA has an open reading frame which codes for a 392-residue polypeptide of Mr = 43,500 with a hydrophobic NH2-terminal sequence which appears to be a signal peptide. An alignment of this amino acid sequence with 1...
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We isolated and analyzed dolichols from fifth stadium larvae of Manduca sexta, in an effort to determine if M. sexta produces ethyl-branched dolichols. Like other lepidopterans, this animal is known to produce the ethyl-branched, homoisoprenoid juvenile hormones. However, we were unable to detect any ethyl-branched dolichol homologues. Manduca sexta larvae at this stage do contain the common eu...
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Many serine proteinase inhibitors of the serpin superfamily have evolved in vertebrates and invertebrates to regulate serine proteinase cascades that mediate the host defense responses. We have isolated an immune-responsive serpin from the tobacco hornworm, Manduca sexta. This inhibitor, M. sexta serpin-3, contains a reactive site loop strikingly similar to the proteolytic activation site in pr...
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ژورنال
عنوان ژورنال: Structure
سال: 1999
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(99)80013-6